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Author: ironjusticeDate: 18 Jun
"Porphyria cutanea tarda should be considered for scleroderma"
Nippon Rinsho. 1995 Jun;53(6):1463-7.Links
[Scleroderma and porphyria cutanea tarda][Article in Japanese]
Tsukazaki N, Okada S, Yoshida H.
Department of Dermatology, Nagasaki University School of Medicine.
Examination was made of sclerodermoid changes in porphyria cutanea
tarda (PCT) and PCT in association with true scleroderma. Although
sclerodermoid change in PCT is rare in Japan, it is important in the
diagnosis of PCT when there are few other clinical signs
characteristic of PCT. In the present case, slight improvement in
cutaneous sclerosis was noted following treatment for PCT, but
pulmonary changes somewhat intensified. The reason for the association
of PCT with progressive systemic sclerosis (PSS) remains obscure.
Elevated uroporphyrin due to PCT may possibly increase cutaneous
sclerosis in PSS. A diagnosis of PCT should be considered for patients
presenting scleroderma, since it is difficult to distinguish
sclerodermoid changes from true scleroderma.
PMID: 7616663 [PubMed - indexed for MEDLINE]
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