Re: Polyunsaturated fatty acids as antioxidants.
On Jul 2, 10:20 am, "rs10...@yahoo.com" <rs10...@yahoo.com> wrote:
> Pharmacol Res. 2008 May 18. [Epub ahead of print]
>
> Polyunsaturated fatty acids as antioxidants.
>
> Richard D, Kefi K, Barbe U, Bausero P, Visioli F.
>
> Laboratory of ĞMicronutrients and Cardiovascular Diseaseğ, UMR7079,
> UPMC Univ 06, Paris, France.
>
> The susceptibility of fatty acids to oxidation is thought to be
> directly dependent on their degree of unsaturation. However, some in
> vitro and in vivo studies suggest that the relation between chemical
> structure and susceptibility to oxidation is not as straightforward as
> hypothesized from theoretical viewpoints. Indeed, long chain
> polyunsaturated fatty acids (LC-PUFAs) might be less oxidizable than
> others under specific experimental conditions. We investigated the
> free radical-scavenging potential of PUFA and the production of
> reactive oxygen/nitrogen (ROS/RNS) species by human aortic endothelial
> cells (HAECs) supplemented with different fatty acids. Fatty acid
> micelles scavenged superoxide in an unsaturation-dependent manner, up
> to eicosapentaenoic acid, which was the most effective fatty acid.
During this "scavenging" the PUFAs turn to lipid hydroperoxides which
are even worst than the simple ROS/RNS.
> Supplementation of HAEC with polyunsaturated fatty acids of the omega
> 3 series resulted in lower formation of ROS, as compared with cells
> supplemented with saturates, monounsaturates, or polyunsaturates of
> the omega 6 series.
Cells in culture don't need gal bladder to get rid of the lipid
peroxide garbage afterwards.
> This effect was maximal at concentrations of
> 10muM. The effects of omega 3 fatty acids on reactive species
> production appear to be stronger when ROS were evaluated, as a milder,
> albeit significant effect was observed on RNS generation. Based on in
> vivo data showing ******* reduced excretion of lipid peroxidation products
> after omega 3 intake *******
I would like to see the direct evidence for this, cannot get to the
full text unfortunately :-(
Taka
> and our data on ROS production and direct
> superoxide scavenging by LC-PUFAs, notably those of the omega 3
> series, we propose that this series of fatty acid might act as
> indirect anti- rather than pro-oxidant in vascular endothelial cells,
> hence diminishing inflammation and, in turn, the risk of
> atherosclerosis and cardiovascular disease.
>
> PMID: 18583147 [PubMed - as supplied by publisher]
MattLB
