On Jul 7, 4:42 pm, Taka <taka0...@gmail.com> wrote:
> On Jul 4, 10:27 pm, MattLB <mat...@angelfire.com> wrote:
>
> > On Jul 4, 3:02 am, Taka <taka0...@gmail.com> wrote:
>
> > > On Jul 4, 1:13 am, MattLB <mat...@angelfire.com> wrote:
>
> > > > it's not a negative feedback
> > > > mechanism where increased AA inhibits the enzymes, it's a feed-forward
> > > > mechanism where the precursors i.e. LA and LNA inhibit their own
> > > > conversion to AA or EPA/DHA.
>
> OK, this "feed-forward mechanism" of yours looks
It's not mine, I was just commenting on the mechanism laid out in that
blog.
> like a simple
> competitive inhibition of the hot LA and ALA (deuterated) with the
> cold LA when given in excess (PMID: 7914092). The conversion rate is
> the same, just the labeled molecule becomes more diluted and is
> therefore less abundant in the end product. Never heard of substrate
> inhibiting its enzyme otherwise.
There are enzymes where that happens. When the concentration of
substrate becomes high enough, more than one molecule can end up in
the active site and thereby inhibit the reaction.
MattLB
MattLB
