On Jul 4, 10:27 pm, MattLB <mat...@angelfire.com> wrote:
> On Jul 4, 3:02 am, Taka <taka0...@gmail.com> wrote:
>
> > On Jul 4, 1:13 am, MattLB <mat...@angelfire.com> wrote:
>
> > > it's not a negative feedback
> > > mechanism where increased AA inhibits the enzymes, it's a feed-forward
> > > mechanism where the precursors i.e. LA and LNA inhibit their own
> > > conversion to AA or EPA/DHA.
OK, this "feed-forward mechanism" of yours looks like a simple
competitive inhibition of the hot LA and ALA (deuterated) with the
cold LA when given in excess (PMID: 7914092). The conversion rate is
the same, just the labeled molecule becomes more diluted and is
therefore less abundant in the end product. Never heard of substrate
inhibiting its enzyme otherwise.
Taka
MattLB
