Herbal Eczema Treatment -
Longines Replica -
Replica Corum -
Eladó Nyaraló -
Venereal WartsSubject: Oxidative Stress-activated JNK
Author: ironjustice@aol.comDate: 26 Apr 2008
Hydrogen peroxide promotes Abeta production through JNK-dependent
activation of gamma -secretase.
Shen C, Chen Y, Liu H, Zhang K, Zhang T, Lin A, Jing N
J Biol Chem 2008 Apr 23.
Accumulation of senile plaques composed of amyloid beta-peptide
(Abeta) is a pathological hallmark of Alzheimer's disease (AD), and
Abeta is generated through the sequential cleavage of amyloid
precursor protein (APP) by beta- and gamma-secretase. Although
oxidative stress has been implicated in AD pathogenesis by inducing
Abeta production, the underlying mechanism remains elusive. Here we
show that the pro-oxidant hydrogen peroxide (H2O2) promotes Abeta
production through c-Jun N-terminal kinase (JNK)-dependent activation
of gamma-secretase. Treatment with H2O2 induced significant increase
in the levels of intracellular and secreted Abeta in human
neuroblastoma SH-SY5Y cells. While gamma-secretase-mediated cleavage
of APP or C99 was enhanced upon H2O2 treatment, expression of APP or
its alpha-/beta-secretase-mediated cleavage was not affected.
Silencing of the stress-activated JNK by siRNA or the specific JNK
inhibitor SP600125 reduced H2O2-induced gamma-secretase-mediated
cleavage of APP. JNK activity was augmented in human brain tissues
from AD patients, and active JNK located surrounding the senile
plaques in the brain of AD model mouse. Our data suggest that
oxidative stress-activated JNK may contribute to senile plaques
expansion through the promotion of gamma-secretase-mediated APP
cleavage and Abeta production.
The Journal of biological chemistry [J Biol Chem]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
ironjustice