Cardiovascular disease and arachidonic acid

Simple help for these FADS1,2 mutants would be going EFAD ... Taka

Lipids. 2008 Apr;43(4):289-99. Epub 2008 Mar 5.

SNPs of the FADS gene cluster are associated with polyunsaturated
fatty acids in a cohort of patients with cardiovascular disease.

Malerba G, Schaeffer L, Xumerle L, Klopp N, Trabetti E, Biscuola M,
Cavallari U, Galavotti R, Martinelli N, Guarini P, Girelli D, Olivieri
O, Corrocher R, Heinrich J, Pignatti PF, Illig T.
Department of Mother and Child, and Biology-Genetics, Section of
Biology and Genetics, University of Verona, Verona, Italy.

Polymorphisms of the human Delta-5 (FADS1) and Delta-6 (FADS2)
desaturase genes have been recently described to be associated with
the level of several long-chain n-3 and n-6 polyunsaturated fatty
acids (PUFAs) in serum phospholipids. We have genotyped 13 single
nucleotide polymorphisms (SNPs) located on the FADS1-FADS2-FADS3 gene
cluster (chromosome 11q12-13.1) in 658 Italian adults (78% males; mean
age 59.7 +/- 11.1 years) participating in the Verona Heart Project.
Polymorphisms and statistically inferred haplotypes showed a strong
association with arachidonic acid (C20:4n-6) levels in serum
phospholipids and in erythrocyte cell membranes (rs174545 adjusted P
value for multiple tests, P < 0.0001 and P < 0.0001, respectively).
Other significant associations were observed for linoleic (C18:2n-6),
alpha-linolenic (C18:3n-3) and eicosadienoic (C20:2n-6) acids. Minor
allele homozygotes and heterozygotes were associated to higher levels
of linoleic, alpha-linolenic, eicosadienoic and lower levels of
arachidonic acid. No significant association was observed for
stearidonic (C18:4n-3), eicosapentaenoic (C20:5n-3) and
docosahexaenoic (C22:6n-3) acids levels. The observed strong
association of FADS gene polymorphisms with the levels of arachidonic
acid, which is a precursor of molecules involved in inflammation and
immunity processes, suggests that SNPs of the FADS1 and FADS2 gene
region are worth studying in diseases related to inflammatory
conditions or alterations in the concentration of PUFAs.
PMID: 18320251

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