> On Jul 10, 11:01 pm, François Rose <fr.r...@free.fr> wrote:
>
>
>
>
>
> > On Jul 10, 12:59 pm, François Rose <fr.r...@free.fr> wrote:
>
> > > > > François Rose
> > > > > PS to rs1000: just curious, when you wrote "So they published it
> > > > > afterall....
> > > > > did you mean that the authors were possibly a bit reluctant to publish
> > > > > these results (because the resveratrol life extending effect was not
> > > > > seen in normal diet and CR diet animals)?
>
> > > François Rose- Hide quoted text -
>
> > > - Show quoted text -
>
> > Thanks, Jay, for the copy of the full text
>
> Thanks for the report Francois.
>
> > MAX LIFESPAN (= mean of the final 20% mice !!!!!!!!!!)
> > standard diet (regardless resveratrol):139 +/- 1 weeks
> > every other day feeding (without RSV):144
> > every other day feeding (with low dose RSV((100 mg/kg of
> > food)(7.6 ± 0.2 mg/kg/day which equals 1.27mg/kg/day for a human (I
> > have to divide by 6 because the animals were mice):147 weeks
>
> Your calculations are not very accurate. Dividing by 7,3 rather than 6
> should give more accurate numbers since the metabolism of mice is
> approximately 7,3 times faster than that of humans. This would give a
> dose of:
> 7,6mg/kg / 7,3 = 1,0mg/kg for humans if one calculates the dose based
> on the amount per body weight. You can also see that your number is
> suspiciously high if you calculate the dose based on the amount per kg
> of food given in the full text. As you report the dose was 100mg/kg
> food. Usually this is on a dry weight basis. On a dry weight basis a
> 70kg adult human eats roughly 500g of food daily which gives about
> 50mg per day or 50mg/70kg = 0,71mg/kg body weight of resveratrol. This
> is even further from your number of 1,27mg/kg/day than what I get
> using the conversion factor of 7,3. To see how I estimated that a 70kg
> adult human eats roughly 500g of food daily on a dry weight basis see
> the last post in this discussion:http://tinyurl.com/5ryqad
>
> > every other day feeding (with high dose RSV (400 mg/kg of
> > food)(30.4 ± 0.6 mg/kg/day which equals 5mg/kg/day for a human):143
> > weeks
>
> Using a conversion factor of 7,3 the numbers for the high dose
> resveratrol group amount to:
> 30,4mg/kg / 7,3 = 4,2mg/kg body weight daily for humans if one
> calculates the dose based on the amount per body weight, and
> 400mg/kg x 0,5kg / 70kg = 2,9mg/kg body weight daily for a 70kg human
> if one calculates the dose based on the amount per kg of food given.- Hide quoted text -
>
> - Show quoted text -
could be corrected.
this.
rjk3@my-deja.c…
ironjustice
