Re: Resveratrol supplementation does not extend lifespan in ad libitum-fed rodents.
On Jul 10, 11:01 pm, François Rose <fr.r...@free.fr> wrote:
> On Jul 10, 12:59 pm, François Rose <fr.r...@free.fr> wrote:
>
>
>
> > > > François Rose
> > > > PS to rs1000: just curious, when you wrote "So they published it
> > > > afterall....
> > > > did you mean that the authors were possibly a bit reluctant to publish
> > > > these results (because the resveratrol life extending effect was not
> > > > seen in normal diet and CR diet animals)?
>
> > François Rose- Hide quoted text -
>
> > - Show quoted text -
>
> Thanks, Jay, for the copy of the full text
Thanks for the report Francois.
> MAX LIFESPAN (= mean of the final 20% mice !!!!!!!!!!)
> standard diet (regardless resveratrol):139 +/- 1 weeks
> every other day feeding (without RSV):144
> every other day feeding (with low dose RSV((100 mg/kg of
> food)(7.6 ± 0.2 mg/kg/day which equals 1.27mg/kg/day for a human (I
> have to divide by 6 because the animals were mice):147 weeks
Your calculations are not very accurate. Dividing by 7,3 rather than 6
should give more accurate numbers since the metabolism of mice is
approximately 7,3 times faster than that of humans. This would give a
dose of:
7,6mg/kg / 7,3 = 1,0mg/kg for humans if one calculates the dose based
on the amount per body weight. You can also see that your number is
suspiciously high if you calculate the dose based on the amount per kg
of food given in the full text. As you report the dose was 100mg/kg
food. Usually this is on a dry weight basis. On a dry weight basis a
70kg adult human eats roughly 500g of food daily which gives about
50mg per day or 50mg/70kg = 0,71mg/kg body weight of resveratrol. This
is even further from your number of 1,27mg/kg/day than what I get
using the conversion factor of 7,3. To see how I estimated that a 70kg
adult human eats roughly 500g of food daily on a dry weight basis see
the last post in this discussion: http://tinyurl.com/5ryqad
> every other day feeding (with high dose RSV (400 mg/kg of
> food)(30.4 ± 0.6 mg/kg/day which equals 5mg/kg/day for a human):143
> weeks
Using a conversion factor of 7,3 the numbers for the high dose
resveratrol group amount to:
30,4mg/kg / 7,3 = 4,2mg/kg body weight daily for humans if one
calculates the dose based on the amount per body weight, and
400mg/kg x 0,5kg / 70kg = 2,9mg/kg body weight daily for a 70kg human
if one calculates the dose based on the amount per kg of food given.
rjk3@my-deja.c…
ironjustice
