Re: Resveratrol supplementation does not extend lifespan in ad libitum-fed rodents.
On Jul 10, 12:59 pm, François Rose <fr.r...@free.fr> wrote:
>
> > > François Rose
> > > PS to rs1000: just curious, when you wrote "So they published it
> > > afterall....
> > > did you mean that the authors were possibly a bit reluctant to publish
> > > these results (because the resveratrol life extending effect was not
> > > seen in normal diet and CR diet animals)?
>
> François Rose- Hide quoted text -
>
> - Show quoted text -
Thanks, Jay, for the copy of the full text
MAX LIFESPAN (= mean of the final 20% mice !!!!!!!!!!)
standard diet (regardless resveratrol):139 +/- 1 weeks
every other day feeding (without RSV):144
every other day feeding (with low dose RSV((100 mg/kg of
food)(7.6 ± 0.2 mg/kg/day which equals 1.27mg/kg/day for a human (I
have to divide by 6 because the animals were mice):147 weeks
every other day feeding (with high dose RSV (400 mg/kg of
food)(30.4 ± 0.6 mg/kg/day which equals 5mg/kg/day for a human):143
weeks
high caloric (without RSV):130
high caloric (with low dose RSV((100 mg/kg of
food)(7.6 ± 0.2 mg/kg/day which equals 1.27mg/kg/day for a human (I
have to divide by 6 because the animals were mice):137 weeks
high caloric (with high dose RSV (400 mg/kg of
food)(30.4 ± 0.6 mg/kg/day which equals 5mg/kg/day for a human):135
Regarding max lifespan:
EOD with low RSV is significantly higher than standard diet
High caloric is significantly lower than standard diet
High caloric with low RSV is not significantly different to standard
diet
IOW:
The high dose of resveratrol is not useful for max lifespan (this is
quite questioning about the right dose of resveratrol in
humans!!!!!!!!)
A low dose of resveratrol enhance the max lifespan
* of High caloric group to the one of the standard group
* of every other day feeeding to a significantly higher than the one
of standard group
SURVIVAL RATE CURVES:
EOD and EOD (with high RSV) are almost superposed and these two ones
square a bit the curve of the standard diet survival
EOD with low RSV squares a bit more the curve (and this is significant
when it was compared to the standard diet)
standard diet (with low RSV or no RSV) are almost superposed (low RSV
survival is a bit lower at the beginning!!)
standard diet (with high RSV) squares the curve a little but
all these 3 standard diets survival do not differ significantly with
regard to resveratrol use
High caloric survival is significantly lower than the one of the
standard diet
High caloric with low or high dose of resveratrol do not differ
significantly to the standard diet
Conclusion: quite identical to those of the max lifespan
NOTES FROM THE FULL TEXT:
"At 1 year of age, C57BL/
6NIA mice were placed on a standard control diet (SD) or DR
by every-other-day feeding (EOD) with or without resveratrol."
Once again, this question has to be asked: how was the every other day
procedure implemented? Would that change something?
"Our results are consistent with
the previous observation that the effect of EOD on longevity is
diminished
in older C57BL/6 mice (Goodrick et al., 1990), which is
also true of DR by 40% restriction (Weindruch and Walford,
1982)."
On Jul 9, 11:47 am, r...@my-deja.com wrote:
> Although this summary says "resveratrol did not prolong life in mice
> fed a standard calorie diet. ", two points are worth noting. 1)
> resveratrol plus CR in the form of every-other-day (EOD) feeding DID
> extend lifespan by 15%, and 2) the strain of mice used in this study
> have previously been shown to not respond to either EOD or 40% caloric
> restriction.
The point 2) above is wrong: C57BL/6 mice respond correctly to either
EOD or 40% CR (you can check that in PubMed). If initiated in older
mice, they respond less. (something very normal)
Here they start the restriction or the resveratrol use at 52 weeks
(which can be compared to the survival ratio median : 120 weeks +/-5
weeks)
"The effects of DR on longevity are diminished when the regimen
is initiated at increasing ages (Goodrick et al., 1990; Weindruch
and Walford, 1982), although many of the characteristic
transcriptional changes can be induced rapidly regardless of
age (Cao et al., 2001). Indeed, our EOD feeding regimen was
initiated at 12 months of age, and while average life span was
increased,
the effect did not reach statistical significance, except
in combination with resveratrol (EODLR versus SD). Thus, it is
possible that the age of our animals at the start of the experiment
might have diminished the potential effects of resveratrol on lifespan
in nonobese mice. To address this question, we are following
up with life-span studies in which resveratrol treatment is
begun at weaning. It may also be that resveratrol slows the general
age-related decline but does not impact the specific causes
of death in these mice. Indeed, resveratrol did not suppress
lymphoma, a major cause of mortality in C57BL/6 mice."
>
> One cannot draw definite conclusions as to what exactly resveratrol
> will do in other species of mice, much less in human beings, from this
> study. It does seem likely to be beneficial
I agree with the above;
From the full text: "The major factor contributing to life span
extension in the resveratrol-treated HC groups was a reduction
in the number of deaths attributed to cardiopulmonary distress
(specifically, fatty changes in the liver combined with severe
congestion and edema in the lungs; Table S3)."
So I don't know if it would be more (or less) benefical in humans in
terms of survival rate and max lifespan.
BENEFITS OF RESVERATROL
Resveratrol use shows a significant effect on osteoporosis, cataracts,
locomotor function and vascular function (in standard diet (we don't
have the data for the other diets); so though it did not add lifespan
or survival to the standard diet mice, it improved their lifetime
conditions (I haven't been very deep into that point).
François Rose
rjk3@my-deja.c…
ironjustice
