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Subject: Re: Resveratrol supplementation does not extend lifespan in ad libitum-fed rodents.
Author: rjk3@my-deja.com
Date: 8 Jul
Ref:

On Jul 7, 7:17 am, François Rose <fr.r...@free.fr> wrote:
> On Jul 4, 2:18 pm, r...@my-deja.com wrote:
> <snip>
>
>
>
> > Although this summary says "resveratrol did not prolong life in mice
> > fed a standard calorie diet. ", two points are worth noting. 1)
> > resveratrol plus CR in the form of every-other-day (EOD) feeding DID
> > extend lifespan by 15%, and 2) the strain of mice used in this study
> > have previously been shown to not respond to either EOD or 40% caloric
> > restriction.
>
> > One cannot draw definite conclusions as to what exactly resveratrol
> > will do in other species of mice, much less in human beings, from this
> > study. It does seem likely to be beneficial.- Hide quoted text -
>
> > - Show quoted text -
>
> I can't find where you get your 15%.
> I only get this from the given link:http://www.sciencedaily.com/releases/2008/07/080703120402.htm
> "Mice on a high-calorie diet without resveratrol lived the shortest
> length of time and mice on an every-other-day regimen lived the
> longest, regardless of resveratrol treatment."
> I can't find either the name of the strain.
>
> If anyone has access to the data of the different groups, I would be
> interested
>
> François Rose
> PS to rs1000: just curious, when you wrote "So they published it
> afterall....
> did you mean that the authors were possibly a bit reluctant to publish
> these results (because the resveratrol life extending effect was not
> seen in normal diet and CR diet animals)?

You need to read the paper, not the press releases:

Pearson et al., Resveratrol Delays Age-Related Deterioration and
Mimics Transcriptional Aspects of Dietary
Restriction without Extending Life Span, Cell Metabolism (2008), doi:
10.1016/j.cmet.2008.06.011



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